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Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones

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dc.authorid0000-0002-2289-7950
dc.authorid0000-0002-0841-1299
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorErtaş, Merve
dc.contributor.authorCankılıç Yılmaz, Meral
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:14Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:14Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı
dc.description.abstractA series of 3-[(4-aryl-2-thiazolyl)hydrazone]-1H-indol-2,3-dione derivatives (2a-f) were designed and synthesized using isatin as starting material. The obtained thiazole compounds were screened to investigate their antituberculosis activity against Mycobacterum tuberculosis H37RV (ATCC 27294). Among them, two compounds 2c and 2d were displayed antitubercular potential two-fold greater than standard drugs.
dc.identifier.citationYurttaş, L., Ertaş, M., Cankılıç Yılmaz, M. ve Demirayak, Ş. (2017). Synthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones. Acta Pharmaceutica Sciencia, 55(1), 51-58. https://dx.doi.org/10.23893/1307-2080.APS.0554
dc.identifier.doi10.23893/1307-2080.APS.0554
dc.identifier.endpage58
dc.identifier.issn1307-2080
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage51
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1104
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0554
dc.identifier.volume55
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversity of Istanbul
dc.relation.ispartofActa Pharmaceutica Scienciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntimycobacterial Activity
dc.subjectIsatin
dc.subjectIndole
dc.subjectThiazole
dc.subjectAntimycobacterial Activity
dc.titleSynthesis and antimycobacterial activity evaluation of isatin-derived 3- [(4-aryl-2-thiazolyl])hydrazone]-1H-indol-2,3-diones
dc.typeArticle

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