A pilot study on effects of combination usage of curcumin and melatonin on cisplatin treatment

Abstract

Cisplatin is an antitumor drug widely used in the treatmentof many malignant tumors. And also some studies show thatmelatonin and curcumin have antitumor activity via several mech-anisms including theirs in addition to theirs potent antioxidantactions. This study was performed to evaluate the effect of cur-cumin and melatonin on the cytotoxicity induced by cisplatin inthe human breast cancer cell line (MCF-7). The cells were treatedwith melatonin or cisplatin or curcumin for 24 and 48 h. Cellviability was quantified using the 3-(4,5-dimethyl-2-thiazolyl)-