Effect of glabridin on microvascular permeability of plasma proteins induced by carrageenan

Abstract

In present study, investigate the anti-inflammatory effects of glabridin (GLA) in the carrageenan-induced paw edema test of rats. Inflammation is an answer to the body's immune response to various stimuli such as physical trauma, various antigens chemicals, microorganisms radiation- damaged tissues. The cause of this edema is the increase of vascular permeability. an increase in local blood flow as well as the penetration of neutrophils and macrophages into the inflamed tissue. The current study aimed to determine the mechanism of microvascular leakage on carrageenan (CAR)-induced paw. edema of GLA. Therefore 10, 20 and 40 mg/kg doses of GLA were given intraperitoneal 3 days before intraplantar administration of CAR by using Evans blue (EB) method and by measuring paw thickness with electronic digital calipers. As a result, GLA inhibited both edema and microvascular leak. The results of our study suggest that pretreat-GLA to CAR -induced paw edema of rats via anti-inflammatory potential through inhibition of parameters such as microvascular escape and anti-edematous effect. These findings may be a new treatment of inflammation by anti-protein leakage of GLA.