Atherogenic index of plasma and triglyceride- glucose index to predict more advanced coronary artery diseases in patients with the first diagnosis of acute coronary syndrome

Abstract

OBJECTIVE: Coronary heart dis-ease (CHD) is the most common cause of mor-tality and morbidity. Acute coronary syndrome (ACS) is the most advanced form of the CHD spectrum. The triglyceride-glucose index (TGI) and atherogenic plasma index (AIP) are asso-ciated with future cardiovascular events. This study investigated the association of these pa-rameters with the severity of CAD and prognosis in the first-diagnosed ACS patients.PATIENTS AND METHODS: Our study was designed retrospectively, including 558 patients. Patients were divided into four subgroups: high and low TGI and high and low AIP. SYNTAX scores, in-hospital mortality, major adverse car-diac events (MACE), and survival were com-pared at 12-month follow-up.RESULTS: More three-vessel disease and high-er SYNTAX scores have been detected in the high AIP and TGI groups. More MACEs have been ob-served in high AIP and TGI groups than low groups. AIP and TGI were found to be independent predic-tors for SYNTAX = 23. While AIP has been found to be an independent risk factor for MACE, TGI has not been detected as an independent risk factor. In addition to AIP, age, three-vessel disease, and low-er EF were the independent risk factors for MACE. Survival was lower in high TGP and AIP groups.CONCLUSIONS: AIP and TGI are costless bedside parameters that can be easily calculat-ed. These parameters can predict the severity of CAD in first-diagnosed ACS patients. Besides, AIP is an independent risk factor for MACE. AIP and TGI parameters can guide our treatment in this patient population.