Erratum to: Mutant SOD1 protein increases Na(v)1.3 channel excitability

Abstract

Firing patterns of a mammalian neuron in response to changes in Nav conductance induced by hSOD1A4V. a At the baseline (see Methods), there is no predicted spontaneous firing as modeled using NEURON software (left; resting membrane potential ?62 mV). Transition from silence to firing was observed first at a conductance of 0.29 Siemens/cm2 (right). b When the Nav conductance in the model is increased by 90% (from 0.25 to 0.475 Siemens/cm2 , which is the mean increment in conductance recorded experimentally), the model fires spontaneously (left).