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DNA methylation pattern of TM6SF2 influences NAFLD progression in genotype-dependent manner

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dc.authorid0000-0002-1240-7233
dc.contributor.authorUlukan, Burge
dc.contributor.authorYiğit, Buket
dc.contributor.authorYılmaz, Onur
dc.contributor.authorCömert, Melis Cansu
dc.contributor.authorErkan, Mert
dc.contributor.authorAdalı, Gupse
dc.contributor.authorDayangaç, Murat
dc.contributor.authorZeybel, Müjdat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:37Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.descriptionInternational Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL) -- APR 10-14, 2019 -- Vienna, AUSTRIA
dc.descriptionWOS: 000463481702178
dc.description.abstractBackground and aims: Non-alcoholic fatty liver disease (NAFLD) arises due to complex interaction of genetic and environmental factors. Evidence suggests that transmembrane 6 superfamily member 2 (TM6SF2) E167K variant is associated with NAFLD susceptibility and progression. The loss of function mutation in TM6SF2 plays a pivotal role in hepatic lipid accumulation, however, it remains unknown if there is an interplay between genetic and epigenetic mechanisms modifying disease pathogenesis. In this study, we aimed to investigate whether epigenetic marks of TM6SF2 could affect development of hepatic steatosis and fibrosis.
dc.description.sponsorshipEuropean Assoc Study Liveren_US
dc.identifier.citationUlukan, B., Yiğit, B., Yılmaz, O., Cömert, M. C., Erkan, M., Adalı, G. ... Zeybel, M. (2019). DNA methylation pattern of TM6SF2 influences NAFLD progression in genotype-dependent manner. International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL) içinde (e549-e549. ss.). Vienna, Austria, April 10-14, 2019. https://dx.doi.org/10.1016/S0618-8278(19)31090-4
dc.identifier.doi10.1016/S0618-8278(19)31090-4
dc.identifier.endpagee549
dc.identifier.issn0168-8278
dc.identifier.issn1600-0641
dc.identifier.issue1
dc.identifier.startpagee549
dc.identifier.urihttps://dx.doi.org/10.1016/S0618-8278(19)31090-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1680
dc.identifier.volume70
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofInternational Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDNA
dc.subjectTM6SF2
dc.subjectNAFLD
dc.subjectGgenotype-Dependent Manner
dc.titleDNA methylation pattern of TM6SF2 influences NAFLD progression in genotype-dependent manner
dc.typeConference Object

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