Comparison of 3 doses of aloe vera and burn drugs in market on burnt rat models

Abstract

Burn injuries are an incident that can have serious traumatic consequences. Degree of tissue damage depends on height of heat and duration of contact. It can be classified as 4 different burn degrees. Herbal treatments can be applied for alleviating the symptoms alongside with pharmacological treatments in clinic. Aloe vera are used for burn cases for so many years because of its antiinflammatory, antiviral, antifungal, antibacterial, antidiabetic and rapid burn wound healing effects. Our aim in this study is to compare different doses of Aloe vera gel with burn medications in market. 48 female Sprague-Dawley rats divided into 8 groups (negative control, positive control, Silverdin®, Bepanthol®, Sudocrem®, Aloe vera 30 mg, Aloe vera 60 mg, Aloe vera 90 mg). For burn modelling, back of the rats were exposed to 90 o C hot water which in the 1,5 cm diameter falcon tube for 10 seconds (burnt area: 7,069 cm2). After the modelling, serum physiologic was applied to each rat. Their treatments were always given at the same time. Experimental study was carried out with 14 numbered approval of Istanbul Medipol University Animal Experiments Local Ethical Committee. Obtained data were evaluated with SPSS v21 programme. After 15 days treatment, 30 mg of Aloe vera was more effective than Silverdin® cream (Aloe vera decreased burnt area: 3,064 cm2, Silverdin® decreased burnt area: 3,731 cm2). The most effective drug among these medications is Sudocrem® with decreased burnt area 2,302 cm2. Consequently, it can be seen that Sudocrem® is the most effective drug when comparing with these medications for burn treatment, and 30 mg dose of Aloe vera is better than Silverdin® cream.