Correlationship between plasma osteopontin levels and echocardiography parameters in patients with idiopathic dilated cardiomyopathy

Abstract

Background: Osteopontin (OPN) has been found to be elevated in patients with heart failure (HF). The relationship between OPN and severity of HF has not been widely studied. The aim of this study was to assess correlation of plasma OPN level as a cardiac remodelling biomarker with echocardiographical parameters in patients with idiopathic dilated cardiomyopathy (DCM). Method and results: 62 patients who have idiopathic DCM were included prospectively. Plasma OPN level was determined with a commercially available human OPN enzyme immunoassay (EIA) kit according to its protocol. Echocardiographical parameters were measured according to guidelines. There was no correlation between plasma OPN levels and echocardiographical parameters, NYHA functional capacity, and BNP. Mean plasma OPN level was slightly higher in moderate to severe HF group (NYHA III-IV, n=21) than mild HF group (NYHA I-II, n=41) but it was not statistically significant (6.47±1.92 vs 6.55±2.09, p:0.935). In addition, plasma OPN levels did not show significant difference between idiopathic DCM patients with restrictive pattern and non-restrictive pattern (5.9±1.6 vs 6.72±2.05, p:0.130). Conclusion: We could not find any relation between plasma OPN levels and severity of heart failure in patients with idiopathic DCM.