Coumarins from the Dichloromethane Root Extract of Heptaptera triquetra and Their Cytotoxic Activities

Abstract

A known dihydrofuranocoumarin ester; deltoin (1), together with five known sesquiterpene coumarin ethers; umbelliprenin (2), farnesyl scopoletin (3), karatavicinol (4), colladonin (5), colladin (6), and a novel sesquiterpene coumarin ether; 14 '-hydroxybadrakemin (7) were isolated from the cytotoxic dichloromethane extract of the roots of Heptaptera triquetra. The cytotoxic activity of the isolated coumarins were evaluated against COLO205 (colon), KM12 (colon), A498 (renal) and UO31 (renal) cancer cell lines.