Prognostic significance of SERPINB1 expression in gliomas

Abstract

Glioblastoma (GB) is the most prevalent and aggressive brain tumor with high morbidity. Determination of tumor initiative and prognostic factors are ultimately needed for therapy options. The effects of Serine Protease Inhibitor (SERPIN) B1 on tumor progression have been reprted in several cancer types including breast and lung cancers. However, the relation between SERPINB1 expression levels and glioma progression is still to be elucidated.