Post-trauma acinetobacter baumannii meningitis treatment approach

Abstract

Acinetobacter baumannii, associated with nosocomial infections, is considered a significant mortality risk if not adequately addressed. A. baumannii infections typically occur after surgery or trauma. Our patient developed complicated A. baumannii meningitis with lateral ventriculitis and a lumbar abscess post-surgery following a fall. The patient was treated with a 21-day regimen of intrathecally administered colistin and polymyxin B. Following this therapeutic period, the patient's condition improved, leading to successful recovery and subsequent discharge. This case report highlights the effectiveness of intrathecal administration of antibiotics, which normally have limited potential for crossing the blood-brain barrier, in improving survival outcomes in multi-drug-resistant nosocomial meningitis.