Efficacy of quadrivalent HPV vaccine for vulvar condyloma recurrence

Abstract

Aim: We tried to assess both prophylactic and therapeutic efficacies of quadrivalent vaccine for vulvar condylomas. Material and Methods: Thirty three women with vulvovaginal condylomas and variable degree of cervical preinasive lesions were treated with cauterization at gynecological oncology clinic of Zeynep Kamil Women and children’s health Training and Research hospital between 2006 to 2014. After cauterization treatment, subjects were vaccinated by quadrivalent HPV vaccine at 0, 2 and 6th months from the treatment. Subjects were followed for 48 months by repeat cervical smears/year and routine urogenital examination. Results: Among 33 cases with vulvar condylomas, there were 6 (18 %) cases with HGSIL, 4 (12 %) cases with ASCUS, 8 (24 %) cases with LGSIL and 15 (46 %) cases with normal cervical smear. Colposcopy directed biopsy revealed 3 (9 %) cases with CIN1, 1 (3 %) case with CIN 3, 29 (88 %) cases with normal histopathology. Distribution of HPV screening results were as follows:HPV 16 in 2 (6 %) cases, HPV 35 in 1 (3 %) case, HPV 56 in 1 (3 %) case, there were 18 (54 %) cases with HPV negative result and 11 (34 %) cases with low risk HPV type. Condyloma recurrence was observed in 4 (12 %) cases. There was only 1 (3 %) case of women with abnormal smear (LGSIL) in control smears during 48 months of follow up. Conclusion: In our study, we included only regularly followed women through 48 months period, and our data revealed lowered condyloma recurrence after cauterization and quadrivalent vaccination.