Cytotoxic activity of the fruit extracts of heptaptera cilicica (boiss. & balansa) tutin

Abstract

The fruit extracts of Heptaptera cilicica (Boiss. & Balansa) Tutin were screened for cytotoxic activities on the colon (COLO205 and KM12) and kidney (UO31 and A498) cancer cell lines. The highest cytotoxic activities were observed in the dichloromethane extract of the fruits with IC50 values of 12.1 mg/mL and 12.2 mg/mL on the COLO205 and KM12 cell lines, respectively. In contrast, the ethyl acetate extract of the fruits exhibited moderate cytotoxic activity with IC50 values of 33.6 mg/mL and 37.2 mg/mL against the COLO205 and KM12 cell lines. Dichloromethane and ethyl acetate extracts of the fruits exhibited weak cytotoxic activity against the UO31 and A498 cancer cell lines with IC50 values greater than 50 mg/mL. Aqueous-methanol extract of the fruits showed cytotoxic activity against all cancer cell lines with IC50 value greater than 50 mg/mL.