Evaluation of the effects of adipocytokines on prognosis in ischemic cerebrovascular events

Abstract

Objective: Leptin and adiponectin are the most important adipocytokines and recent studies showed that they may have role in the etiology of ischemic stroke. However, the effect of adipocytokines on stroke is not yet well understood, and related studies are confusing. The aim of this study was to investigate the effects of serum leptin and adiponectin levels on patients with acute ischemic stroke who were admitted to hospital within 24 hours of stroke. Materials and Methods: A total of 59 patients with acute ischemic stroke and 24 healthy individuals similar in age and sex to the patients were enrolled in the study. The Rankin disability scale was performed in order to detect the severity of stroke. Levels of serum leptin and adiponectin were detected using an enzyme-linked immunosorbent assay. In addition, the outcomes of the patients were calculated through differences between the first day Rankin score and the 30th day Rankin score. Results were compared and the relation with prognosis was investigated. The correlation of leptin and adiponectin levels with stroke severity was analyzed. Results: Thirty-four male and 25 female patients were included in this study. Leptin levels of patients were higher than in the control group. Adiponectin levels did not differ between the patient and control groups. There was no correlation between serum adipocytokine levels and the modified Rankin scale. Conclusion: Serum leptin and adiponectin levels are not associated with the prognosis of ischemic stroke. Even though high levels of leptin may associate with ischemic stroke, this study was not able to show an association with stroke prognosis.Leptin ve adiponektin, adipositokinlerin en önemlileridir ve son yıllarda yapılan çalışmalarda iskemik serebrovasküler olay etiyolojisinde rolü olduğu düşünülmektedir. Ancak adipositokinlerin inme üzerine etkisi ile ilgili yapılan çalışmaların sonuçları çelişkilidir. Bu çalışmada, iskemik inme tanısı ile ilk 24 saat içerisinde hastanemiz acil servisine başvuran hastaların serum leptin ve adiponektin düzeylerinin prognoz ile ilişkisini değerlendirmeyi amaçladık.