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In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0002-8084-7855
dc.contributor.authorKaya, Yasin Emre
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBilir, Bülent
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2021-02-05T12:34:52Z
dc.date.available2021-02-05T12:34:52Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues. Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disc tissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreated samples were statistically evaluated using an alpha signifiance value of < 0.05. Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control group samples (P < 0.05). Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.
dc.identifier.citationKaya, Y. E., Yılmaz, İ., Karaarslan, N., Bilir, B., Yaşar Şirin, D. ve Özbek, H. (2020). In-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus. Annals of Medical Research, 27(7), 1855-1859. https://doi.org/10.5455/annalsmedres.2020.03.224
dc.identifier.doi10.5455/annalsmedres.2020.03.224
dc.identifier.endpage1859
dc.identifier.issn2636-7688
dc.identifier.issue7
dc.identifier.startpage1855
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.03.224
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6532
dc.identifier.volume27
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnnals of Medical Research Publishing Inc
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChondroadherin Gene
dc.subjectCartilage Oligomatrix Protein
dc.subjectInterleukin-1beta
dc.subjectIntervertebral Disc Cell Culture
dc.subjectMatrix Metalloproteinase
dc.subjectTigecycline
dc.titleIn-vitro evaluation of the effects of tigecycline on annulus firosus and nucleus pulposus
dc.typeArticle

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